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專為小動物模型成像而設(shè)計，集成氣體麻醉和溫度控制以及高靈敏度sCMOS相機的緊湊型結(jié)構(gòu)，460-1320nm波長范圍內(nèi)獲取共配準(zhǔn)熒光和光聲信號，獲取高分辨率深層組織3D圖像。每次掃描可以使用多個激發(fā)波長，多模態(tài)系統(tǒng)可以同時獲取大體積（30-60 cm3）的光聲和熒光數(shù)據(jù)，可以在感興趣的區(qū)域內(nèi)進行光譜分析。除了 3D 分子圖譜外，TriTom 還可以對體內(nèi)生理參數(shù)進行空間解析評估，例如體積血含量和氧合情況，而無需造影劑。TriTom 還為 460 nm 至 1320 nm 激發(fā)的多種熒光團和其他類型的分子探針提供定量成像。憑借如此多功能的成像能力，TriTom 系統(tǒng)非常適合廣泛的臨床前應(yīng)用，包括腫瘤、毒理學(xué)、發(fā)育生物學(xué)、組織工程和再生、神經(jīng)科學(xué)、心血管成像，以及藥物、療法和光學(xué)和熒光成像探針的開發(fā)。
產(chǎn)品特征
集成了3D 光聲和熒光斷層掃描技術(shù)的緊湊型臺式設(shè)計
大體積（30-60 cm3）快速成像掃描（<36 秒），具有出色的分子靈敏度
以高空間分辨率（高達(dá) 150 µm）對解剖、功能和分子體積進行精確的 3D 配準(zhǔn)
可在整個光譜范圍內(nèi)調(diào)節(jié)光學(xué)激發(fā)波長，可在一次掃描中實現(xiàn)多種波長
高靈敏度 sCMOS 熒光相機，配備標(biāo)準(zhǔn)發(fā)射濾光片，可覆蓋常用的熒光探針
集成氣體麻醉管線和可調(diào)節(jié)小鼠支架，操作方便，可重復(fù)進行體內(nèi)縱向研究
單次掃描評估多個微樣本（50 µL 或更少體積），加速造影劑開發(fā)，避免浪費
用戶友好的集成軟件，旨在限度地縮短實驗時間，并在幾秒鐘內(nèi)重建大規(guī)模體積
開放數(shù)據(jù)格式，允許使用第三方軟件進行圖像重建和數(shù)據(jù)管理
參考文獻(xiàn)
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K. Huda, D. J. Lawrence, w. Thompson, S. H. Lindsey, and C. L. Bayer, "in vivo noninvasive systemicmyography of acute systemic vasoactivity in female pregnant mice," Nature Communications, vol14,,2023,doi: 10.1038/s41467-023-42041-8.
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M. R. Chetyrkina et al., "Carbon Nanotube Microscale Fiber Grid as an Advanced Calibration Systemfor Multispectral Optoacoustic lmaging," Acs Photonics, vol. 9, 0, pp. 3429-3439, 2022, doi:10.1021/acsphotonics.2c01074.
M. D. Mokrousov et al, "indocyanine green dye based bimodal contrast agent tested byphotoacoustic/fluorescence tomography setup," Biomed. Opt. Express, vol. 12, no. 6, p. 3181, 2021, doi.10.1364/boe.419461.
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